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6 Catechol-O-methyltransferase (COMT) - COMT has an effect on dopamine signaling in the prefrontal cortex, Whilst the association of satisfied/Val with greater gait effectiveness seems to be due to effect of COMT on tonic dopamine regulation while in the striatum in Adult males only. The associations among COMT, gait and govt functionality ended up affected by gender. The COMT genotype was connected to gait velocity in Males although not in Females.eight Yet another study confirmed that PA ranges, by using dopamine regulation, moderates cognitive and mobility gains by enhancing participation in PA. This system is potentially as a result of genotypes that happen to be connected to increased dopamine function are connected with bigger will increase in PA than genotypes connected with lessen dopamine perform.nine
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